INTRODUCTION Due to demographic changes, it is expected that the incidence of the HL will increase in patients(pts) over 65 years(y), highlighting the need for therapeutic strategies designed specifically for the geriatric population. The objective of this review is to evaluate our everyday life practice and analyze the characteristics, prognostic factors and survival of pts over 65y diagnosed of HL in our center. METHODS This is an observational, retrospective review. A total of 44pts over 65y and diagnosed of HL from May 2005 to December 2015 were included. The Charlson Comorbidity Index (CCI) was used to evaluate the comorbidities. Pts’s and disease’s characteristics are listed in table1. RESULTS The treatment and the response rate are shown in table1. 58% of pts achieved CR and there were only 2 relapses recorded in this group. 16% progressed during treatment (most of them had an advanced stage at diagnosis). 18% did not receive any treatment owe to comorbidities or denial by the pt. The estimated 5y overall survival (OS) was 45%. Mortality rate was 54.5%: half due to the disease itself, 27% as a result of the treatment’s toxicity (60% of this group owe to pulmonary involvement), 14% by other neoplasia and 9% due to comorbidities. In the univariate analysis factors associated with lower survival were a CCI ≥3 and the age >80y, with a 5 y-OS of 28% vs 51% (p = 0.003) and 8% vs 60% (p = 0.0002), respectively. Because of the low sample size it is not rentable to assess a multivariate analysis. CONCLUSIONS Despite the limitations of a retrospective analysis, our study confirms the data published in the literature: elderly patients frequently present mixed cellularity subtype, achieve lower rates of CR and OS, but relapse-free survival is less impaired and present higher toxicity associated with treatment compared to young patients. The fundamental cause of death remains being the disease. The age over 80 years and CCI≥3 are associated with a worse prognosis. The management of patients over 80 years represents a major therapeutic challenge because of the high toxicity and low efficiency of current treatments. It is important to include these patients in clinical trials covering new drugs. The new drugs and new easy geriatric assessment tools, which detect frailty, should assist in the better management of these elderly patients. Our hospital intends to initiate a care protocol that covers the assessment using the CIRS-C and GAH scales.