One-hundred forty-three patients with advanced-stage HL were treated with a dose-dense three-weekly version of the ABVD regimen, which was also dose intensified, in the first 4 cycles, by escalating doxorubicin. Specifications are contained in the published article (Russo F BHJ 166,1,118, 2014). Twelve patients (8.4%) received radiotherapy (RT) on residual mediastinal or extramediastinal bulk disease. Results were compared with a historical series of 111 patients treated with standard ABVD+/-RT. The demographics and clinical characteristics are in Tab1. Ninety-six percent of patients completed the planned 6 cycles (median time=16.8 weeks). Median actual dose intensities were 20.87 (23.11 cycles1-4), 6.72, 3.89 and 248 mg/m2/week for doxorubicin, bleomycin, vinblastine and dacarbazine, respectively. This corresponded to a 66.9% (85.0%, cycles 1-4) increase in dose intensity for doxorubicin, (total dose 380 mg/m2) and of 32% for the other agents, over standard ABVD. Intensified ABVD confirmed to be highly tolerated with low rates of hospitalization during treatment, a low incidence of G3/ G4 events, low post-treatment cardiac and pulmonary toxicities and a very low rate of gonadic toxicity. Only two cases of second cancer were recorded. One-hundred-eleven out of 143 (79%) showed a PET normalization at the end of 2nd cycle. Comparison between intensified and standard ABVD showed complete remission (CR) rates 93.7% in intensified ABVD and 80.2% in standard ABVD, respectively (p=0.002). EFS and OS rates at 7 years were 85.7% vs 68.1% and 93.9% vs 76.3%. At univariate analysis the predictive factors of low CR rate were IPS≥3 ( p=0.032), and PET2pos (p <0.001). At multivariate analysis PET2pos (p<0.001) was the only independent risk factor predictive of low CR rate. Seven-yr EFS was significantly better in patients with PET2neg (log rank 13.2, p<0.001) and in patients with IPS 0-2 (log rank 4.3, p=0.032). At Cox regression analysis PET2 was the only independent factor predictive of EFS. As on 09/2015, one-hundred-thirty-five out of 143 are alive with 131 free of disease (123 in 1stCR,8 in 2ndCR). Intensified ABVD seems to be adequately powered to exploit early disease chemo-sensitivity yielding high percentage of PET2neg , high rate of response and survival, without new severe or critical short and long-term toxicities. Selective use of low dose RT in residual PET+ tissue seems to rescue a subset of patients with bulky disease and suboptimal response.